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Interestingly, there are several mechanisms by which GSH may be involved in the ABCC1-catalyzed ATP-dependent transport of various compounds directly out of the cell: (1) transport of the glutathione S -conjugate, including LTC 4 , (2) GSH-stimulated egress (e.g., vincristine), and (3) GSH-stimulated efflux of the glutathione S -conjugate (e.g., the glutathione S -conjugate of nitroquinoline 1-oxide) (reviewed by Cole and Deeley, 2006)

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[DOI] [PubMed] [Google Scholar] 17.Houschyar K.S., Borrelli M.R., Tapking C., Popp D., Puladi B., Ooms M., Chelliah M.P., Rein S., Pforringer D., Thor D., et al