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Intestinal tryptophan metabolites, such as indole-3-acetic acid (IAA) and indole-3-pyruvate (IPA), function as aryl hydrocarbon receptor (AhR) ligands, activating the AhR and subsequently initiating the Wnt/β-catenin signaling pathway, which significantly promotes chondrocyte proliferation (82)
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References 1.Lowes M.A., Suárez-Fariñas M., Krueger J.G
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