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Blocking GSH synthesis in combination with JMF4073 depletes dTTP/dCTP pools to eradicate T315I-Bcr-Abl leukemia We hypothesize that reducing the GSH level to increase replication stress can render T315I-Bcr-Abl leukemia more susceptible to JMF4073 in vivo
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Retinoids and carotenoids Retinoic acid, an active metabolite of vitamin A, promotes homeostasis and mitigates inflammatory responses in mucous membranes and tissues by increasing the expression of IL-10 and IL-22 (Reference Oliveira, Teixeira and Sato99) , two key anti-inflammatory cytokines (Reference Keir, Yi and Lu100,Reference Wei, Wang and Li101)
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