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Initially, Notch signaling mediates the dedifferentiation of BECs into LPCs, establishing a progenitor pool essential for initiating regeneration under severe hepatic stress
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Furthermore, AGEs have high affinity to neutrophil accessory gene regulator (AGR) (AGE receptor), inhibiting the transendothelial migration and bactericidal ability of neutrophils (Glowacka et al., 2002)
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