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Glutarate is known to be a demanded building block for the production of biopolymers, like aliphatic polyamide 6,5 which is mainly used in the construction industry (Navarro et al., In medicine, l-2HG is used as a diagnostic biomarker for the characterization of various cancer types (Shim et al., Escherichia coli (Knorr et al., In bacteria, l-2HG mainly accumulates under carbon starvation conditions (Marschall et al., Pseudomonadaceae (Zhang et al., Glutarate can be derived from l-lysine by four pathways that converge to 5AVA, which is converted to glutarate by GABA/5AVA aminotransferase (GabT) and the succinate/glutarate semialdehyde dehydrogenase (GabD)