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Additionally, our study identified novel loci and variants that have not been reported in earlier GWAS

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The more reduced mitochondrial [NAD + ]/[NADH] during fasting and DR from increased neural fatty acid oxidation (low capacity in neurons) and ketone body oxidation may slow the mitochondrial malate dehydrogenase 2 (MDH2) enzyme of the MAS, inhibiting flux through the MAS leading to the more reduced cytoplasmic [NAD + ]/[NADH] observed in the brain of animals on the DR diet

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