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There is increasing evidence that the tumour microenvironment (TME) that comprises cancer cells, tumour stroma, blood vessels and immune infiltrate, promotes cancer progression and alters tumour sensitivity to therapy

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In the context of exposure to cigarette smoke, research studies have demonstrated that low levels of LL-37 are associated with a decrease in forced expiratory volume in 1 s (FEV 1 ), which is particularly significant in individuals with deficient vitamin D 3 production (282)