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The third factor is the specific expression of inducible signals, such as Lon protease, which protects mitochondria by interfering with cytochrome c oxidase complex assembly/degradation, and similarly, leads to the induction of NIX (a Bcl-2 family protein that regulates ER/Sarcoplasmic Reticulum (SR) Ca 2+ and mitochondrial membrane potential) and opening of the mitochondria permeability transition pore (MPTP) [36,37]
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there is 59.95% nucleotide similarity and 55 % amino acid similarity between the zebrafish and human loci
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