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Discussion In the present study, we used the Cre-loxP technique to remove IR from chondrocytes, which has enabled us to determine the contribution of insulin signaling through its cognate receptor

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mTOR-AMPK signaling crosstalk While both mTOR and AMPK seem to regulate different pathways, there are key hubs of crosstalk where both converge to regulate homeostatic processes such as autophagy and cell metabolism (Figure 1 and Supplementary Table 1)