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Both alcohol and isoniazid induce CYP2E1 and affect APAP-induced ALI by increasing NAPQI, the hepatotoxic metabolite of APAP, indicating that CYP2E1 may be the major P450 contributing to conversion of APAP to NAPQI (Zand et al., 1993
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Disruption of the gut microbiota caused by antibiotics, infections, poor diet, or stress can lead to dysbiosis [158]
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