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Amelioration of the detrimental impact of hyperglycaemia on osteogenic dysfunction has been reported to be mediated through Nrf2 activation via the Akt/glycogen synthase kinase 3β (GSK3β)/FYN axis and the restoration of SIRT1 expression in MSCs and osteoblasts (236, 237)
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Women with PCOS can present with symptoms affecting various body systems including reproductive, hair and skin, endocrine and psychological
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