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However, major expert groups have looked at the research and concluded that: The evidence is not sufficient to show that screening every adult without symptoms for vitamin D deficiency clearly improves outcomes such as fractures, heart disease or cancer

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Since Nicolau reported the first case of the symptoms as having occurred after intramuscular injection of Bismuth salt for the treatment of syphilis in the early 1920s, cases of Nicolau syndrome have been reported after intramuscular injection of non-steroidal anti-inflammatory drugs, steroids, and other drugs