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These data indicate that genes associated with metabolic ROS generation tend to be upregulated in MZB compared to FoB, suggesting that differences in the control of ROS signaling might contribute to the classical distinctions between these two mature B cell subsets
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Another burden is that fingolimod use is associated with a higher infection rate in MS patients (16% higher than placebo), but there’s no convincing data comparing it with other drugs or drug candidates in this regard (156)
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