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A stylized model shows a weak methionine efflux is responsible for hcy homeostasis We are interested in the dependence of hcy * on the parameter k 0 , which in the stylized model (described in Data Sheet 1) is representative of MS in the methionine cycle: The steady-state of Hcy, Equation (5) is The sensitivity of hcy * to changes in k 0 is dependent on the values of k 1 , k 3 and k −1

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These molecules rise gradually over decades and are now well-established predictors of mortality, cognitive decline, and functional limitation in population studies