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The structural literature on B12-dependent enzymes is the more mechanistically informative body of work
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Novo Nordisk released headline results from the REDEFINE 4 head-to-head trial in February 2026: 809 adults with obesity and at least one comorbidity, randomized to CagriSema 2.4/2.4 mg or tirzepatide 15 mg once weekly for 84 weeks
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