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The phenyl ring of F23 Cagri forms extensive van der Waals contact with L16 Cagri , Y149 1.40 , Y146 1.37 (superscript numbers for receptor residues refer to the class B1 GPCR numbering scheme 17 ), anchoring the peptide segment with the CTR transmembrane (TM) bundle level with the micelle interface

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The anti-inflammatory effect prevents the chronic low-grade inflammation that keeps injured soft tissue in a partial-repair state, cycling between managed pain and flare rather than progressing toward structural restoration