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This reaction of GR with GSSG is regulated by nicotinamide adenine dinucleotide phosphate (NADPH), which is provided as a substrate for supplying electrons to GSSG by NADPH regenerating enzymes, such as glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogenase, NADP + -dependent isocitrate dehydrogenase, malic enzyme, and mitochondrial nicotinamide nucleotide transhydrogenase [24]
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