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Activation of Cdc42-associated tyrosine kinase Ack1 can result in phosphorylation of tyrosine residues 269 and 365 enhancing androgen receptor transcriptional function and promoting androgen independent prostate cell growth (200, 201) and disrupting phosphorylation primarily of tyrosine 269 results in impaired nuclear localization (202)
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doi: 10.1007/s11010-019-03667-9 119 ZhangJBaoYZhouXZhengL
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