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Interestingly, clinical studies show that CYP2D6 (and CYP2E1) is also expressed in the brain and is upregulated in people with AUD (137, 278)

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Another study on a rat model of gouty arthritis, induced by MSU crystals and followed by a 5-day administration of rutin, found that rutin reduced ankle swelling, and the levels of MDA and NO, and improved the activities of GSH-peroxidase, SOD and catalase in rats (25)