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Comparing whole-genome DNA methylation profiles between neurons (positive staining of NeuN, a mature neuron marker) and non-neuronal cells (NeuN negative, presumably most were glial cells) suggested that cell type-specific CG-DMRs were localized to functional regions of the genome, while mCH, which is nearly depleted in non-neuronal cell types, was considered the primary neuron-specific DNA modification (Lister et al., 2013)