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An analysis of 103 G6PD mutants causing G6PD deficiency in humans, as against 52 G6PD sequences from 45 different organisms, has shown that most mutations (74%) are in highly and moderately conserved (50%–99% of similarity) AAs, whereas few mutations are in fully conserved or in poorly conserved AAs ( Fig

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The hexosamine pathway can be activated to enhance O-GlcNAc acylation, potentially leading to IR (Ritter et al., 2015

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