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Bone morphogenetic protein (BMP) signaling, integral to endometrial remodeling, is also dysregulated: BMP2 promotes decidualization via ALK3-mediated upregulation of genes like WNT4 and IGFBP3, while BMP7 inhibits this process, and their imbalance contributes to defective decidualization (50)
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furthermore, CR also reduced the expression of proapoptotic genes Bcl-xS/Bcl-xL, mitochondrial translocation of BAX, release of cytochrome c into cytosol, and caspase-9 activation (Niemann et al., 2010)
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