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American Journal of Clinical Nutrition 80, 1611β1617 [DOI] [PubMed] [Google Scholar] James S.J., Melnyk S., Jernigan S., Cleves M.A., Halsted C.H., Wong D.H
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Using gain- and loss-of-function approaches to manipulate HPA activity, we found that exogenous ACTH acutely increased energy expenditure to a level comparable to norepinephrine (NE), while blockade of endogenous ACTH using a neutralizing antibody or the MC2R antagonist CRN04894 impaired cold-induced thermogenesis
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