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In a study of 40 children with ASD, 75 µg/kg mB12 SC 2 times per week for 3 months given with folinic acid (400 µg twice per day) led to significant improvements on all subscales of the Vineland Adaptive Behavior Scale (VABS), including significant improvements in receptive, expressive, and written communication skills, personal, domestic, and community daily living skills, and interpersonal, play-leisure, and coping social skills