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2 Metabolic mechanisms that may explain links between obesity, MetS, T2DM, and PD It is currently accepted that neuroinflammation and oxidative stress are major factors in PD-related dopaminergic neuron degeneration ( Interestingly, IR, inflammation, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, autophagy, and the ubiquitin–proteasome system (UPS), independently contribute to the onset and aetiopathogenesis of both T2DM and PD
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